AMPA受体在睡眠剥夺损伤学习和记忆功能中的研究进展

Research progress on AMPA receptors in sleep deprivation-induced impairment of learning and memory functions

中文关键词: α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体  睡眠剥夺  学习  记忆

英文关键词: Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors  Sleep deprivation  Learning  Memory

中文摘要:

      睡眠作为人体必不可少的生理活动，对学习、记忆及认知等功能至关重要。睡眠剥夺（SD）在日常生活中十分常见，可通过多种机制损伤学习和记忆功能。α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体是重要的谷氨酸离子型受体，通过介导突触可塑性等机制，在学习和记忆中发挥重要作用，同时睡眠对AMPA受体也有很大的影响。本文综述SD时AMPA受体的变化对突触可塑性、胆碱能受体、炎症反应、疼痛等方面的影响，以及如何影响学习记忆功能，旨在为SD影响学习和记忆功能的机制提供新的思路。

英文摘要:

      As an essential physiological activity in the human body,sleep is crucial for learning, memory, and cognition. Sleep deprivation (SD) is very common in daily life and damages learning and memory through various mechanisms. Alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are important glutamate receptors that play an important role in learning and memory by mediating mechanisms such as synaptic plasticity. While, sleep also effects AMPA receptors. This article will review the effects of changes in AMPA receptors during SD on synaptic plasticity, cholinergic receptors, inflammatory responses, pain, and other aspects, and how they affect learning and memory functions. The aim is to provide new sights into the mechanisms which SD affects learning and memory function.