艾司氯胺酮防治围术期抑郁的研究进展

Research progress in the prevention and treatment effect of esketamine on perioperative depression

中文关键词: 艾司氯胺酮  抑郁  围术期

英文关键词: Esketamine  Depression  Perioperative period

中文摘要:

      抑郁是围术期常见的情绪障碍，无论是术前并存抑郁还是术后新发抑郁，均会影响患者术后康复，且目前缺乏有效的干预措施。相关研究表明，艾司氯胺酮可以缓解围术期抑郁。本文对围术期抑郁、艾司氯胺酮及其抗抑郁机制、艾司氯胺酮在防治围术期抑郁中的应用及其相关不良反应进行综述，以期为艾司氯胺酮的临床应用及围术期抑郁的防治提供参考。

英文摘要:

      Depression is a common mood disorder in perioperative period. Both preoperative depression and postoperative new depression can affect postoperative rehabilitation of patients, and there is a lack of effective intervention measures. Related studies have indicated that esketamine can alleviate perioperative depressive symptoms. In order to provide references for clinical work and reduce the occurrence of perioperative depression, this review summarizes perioperative depression, esketamine and its anti-depression mechanism, the application of esketamine in prevention and treatment of perioperative depression and its related adverse reactions．