瑞马唑仑在围术期器官和系统保护作用中的研究进展

Research progress on organ and system protection of remimazolam during perioperative period

中文关键词: 瑞马唑仑  器官保护  围术期

英文关键词: Remimazolam  Organ protection  Perioperative period

中文摘要:

      瑞马唑仑是一种新型、超短效的苯二氮类镇静麻醉药，作用于γ-氨基丁酸A受体（GABA_AR）α亚单位上的苯二氮类受体，具有镇静、催眠、抗焦虑、心肺影响轻微的效应，在无痛内镜和全身麻醉中的临床应用越来越广泛。器官保护是围术期关注的焦点，对于促进术后恢复、改善预后有重要作用。瑞马唑仑对机体神经系统及心、肺、肝、胃肠道等重要器官具有保护作用，其机制可能与抗炎、抗凋亡、减轻应激反应等有关。本文就瑞马唑仑的器官和系统保护作用及其机制作一综述，为临床应用提供参考。

英文摘要:

      Remimazolam is a new, ultra-short-acting benzodiazepine sedative narcotic drug that acts on γ-aminobutyric acid type A receptor (GABA_AR). Benzodiazepine receptors on the α subunit of GABA_ARR have sedative, hypnotic and anxiolytic effects with mild cardiopulmonary effects. The clinical roles of remimazolam in painless endoscopy and general anesthesia have been gradually discovered. Organ protection is the focus of perioperative process, which has a profound impact on postoperative recovery and prognosis. Remimazolam has a protective effect on the nervous system, heart, lung, liver, gastrointestinal tract and other important organs, and its mechanism may be related to anti-inflammation, anti-apoptosis, and stress reduction. This article reviews the organ and systemprotective effect and mechanism of remimazolam, so as to provide some reference for its clinical application.