Objective: To investigate the impact of intravenous inject esketamine before operation on postoperative fatigue syndrome (POFS) in patients undergoing laparoscopic radical surgery for colorectal cancer. Methods: Sixty-two patients, 41 males and 21 females, aged 34-64 years, BMI 18-25 kg/m2, ASA physical statusⅠ orⅡ, scheduled for laparoscopic radical surgery for colorectal cancer under general anesthesia, were randomly assigned into two groups: the esketamine group (group E) and the control group (group C), 31 patients in each group. Group E received a single intravenous injection of esketamine 0.25 mg/kg 5 minutes before surgery, while group C received sodium chloride 5 ml. The intravenous analgesia program was identical between the two groups. The jugular venous blood samples were taken for determination of serum concentrations of tumor necrosis factor-α (TNF-α) and superoxide dismutase (SOD) 10 minutes before anesthesia, at the end of operation, and 12 and 24 hours after operation. Identity-consequence fatigue scale (ICFS-10) score were performed 1 day before surgery, 3, 5, and 7 days after operation, respectively, and the occurrence of POFS (ICFS-10 score > 24 points) were recorded. The time of extubation and the occurrence of adverse reactions such as coughing, delirium and restlessness during awakening, the complications of systems postoperatively, and the postoperative hospitalization time were recorded. Results: Compared with group C, the concentration of serum TNF-α were significantly decreased while the concentration of serum SOD were significantly increased at the end of operation, 12 and 24 hours after operation (P < 0.05), ICFS-10 score 3, 5, and 7 days after operation, and the incidence of POFS 7 days after operation were significantly decreased (P < 0.05). There were no significant differences in extubation time, coughing, delirium and restlessnes, the complications postoperatively, and postoperative hospitalization time between the two groups. Conclusion: A single intravenous injection of esketamine can reduce the incidence of POFS in patients undergoing laparoscopic radical surgery for colorectal cancer, and no postoperative adverse reactions increased. |