Objective To investigate the effect of transverse thoracic muscle plane (TTP) block on early outcomes after valve replacement under cardiopulmonary bypass(CPB) in elderly patients. Methods Fifty-eight elderly patients, 39 males and 19 females, aged ≥ 65 years, ASA physical status Ⅱ or Ⅲ, and NYHA cardiac function class Ⅱ or Ⅲ, who underwent elective valve replacement under general anesthesia with cardiopulmonary bypass were selected. The patients were randomly divided into two groups by random number table method: transversus pectoralis plane block group (group T) and control group (group C), 29 patients in each. Before anesthesia induction, the patients in group T were located in the bilateral 4-5 costal space by ultrasound, and 025% ropivacaine 20 ml was injected into the intercostal muscle and transverse thoracic muscle. Patients in group C were induced by direct anesthesia. The patients' cognitive function was evaluated by neuropsychological combined scale on the first day before operation and seventh days after operation. The intraoperative sufentanil consumption and incidence of postoperative cognitive dysfunction (POCD) were recorded. The S100β protein was recorded at 5 minutes before skin incision after anesthesia induction, 24 hours after surgery, and 72 hours after surgery. When patients entered the operating room, 5 minutes before skin incision after anesthesia induction, the sternum was sawed, 30 minutes after the start of CPB, 30 minutes after the end of CPB, and out of the operating room, HR and MAP were recorded. Serum IL-6 and TNF-α concentrations were respectively recorded 5 minutes before skin incision after anesthesia induction, 30 minutes after the start of CPB, 30 minutes after the end of CPB, 24 hours after surgery, and 72 hours after surgery. Concentrations of insulin and blood glucose concentrations were recorded, and the insulin resistance (IR) index was calculated 5 minutes before skin incision after anesthesia induction, 30 minutes after the end of CPB, and 72 hours after surgery. The VAS scores at 24 and 72 hours after surgery, mechanical ventilation time, ICU stay time were recorded. Results Compared with group C, the amount of sufentanil used during operation and the incidence of POCD in group T (45% vs 21%) was significantly lower than that in group T (P < 0.05). Compared with group C, the concentration of serum S100β protein 24 hours and 72 hours after operation in group T were significantly decreased (P < 0.05), the HR and MAP of the T group decreased significantly during the sternum was sawed (P < 0.05). Compared with group C, the concentrations of IL-6 in group T were significantly decreased 30 minutes after the start of CPB, 30 minutes after the end of CPB, and 24 hours after surgery (P < 0.05); the concentrations of TNF-α in group T were significantly decreased 30 minutes after the start of CPB, and 30 minutes after the end of CPB (P < 0.05); the IR index of group T were significantly lower 30 minutes after the end of CPB and 24 hours after surgery (P < 0.05). Compared with group C, the VAS score at 24 hours after surgery, mechanical ventilation time and ICU stay time in group T were significantly reduced (P < 0.05). Conclusion Transverse thoracic muscle plane block can effectively reduce the incidence of early POCD after valve replacement under cardiopulmonary bypass in old patients, moreover, it can maintain hemodynamic stability, reduce perioperative inflammatory response, improve IR and promote early outcomes after surgery. |