| Cognitive dysfunction is the impairment of cognitive function caused by various reasons, which seriously affects the quality of life of patients. Old age, past cardiovascular and cerebrovascular diseases, anesthesia and surgery are the most common factors. Autophagy is an intracellular degradation pathway essential for maintaining cellular energy homeostasis, which is closely related to stress, infection, cancer and neurodegenerative diseases.In recent years, numerous studies have shown that autophagy plays an important role in the mechanism of cognitive dysfunction. Abnormal autophagy levels in neurons can disrupt cell homeostasis and, in severe cases, affect patients’ cognitive function. Studies have shown that regulating various autophagy signaling pathways can significantly improve cellular hypoxia, promote energy and substance metabolism, and improve cognitive function, which provides a new idea for the prevention and treatment of clinical cognitive dysfunction. |
