右美托咪定联合地佐辛在ICU机械通气患者中镇痛镇静的效果

Observational study about dezocine combined with dexmedetomidine for sedation and analgesia in ICU patients with mechanical centilation

中文关键词: 右美托咪定  芬太尼  地佐辛  镇静  镇痛

英文关键词: Dexmedetomidine  Fentanyl  Dezocine  Sedation  Analgesia

中文摘要:

      
目的 观察右美托咪定联合地佐辛或芬太尼在ICU机械通气患者术后镇痛镇静的效果。
方法 选择2016年6～12月我院ICU机械通气患者57例,男35例，女22例，年龄18～75岁，将患者按随机数字表法分为三组:右美托咪定组(A组,n=17例)、右美托咪定联合芬太尼组(B组,n=20例)和右美托咪定联合地佐辛组(C组,n=20例)。比较三组患者一般状况、疼痛评分、用药前后MAP和HR、达理想镇痛镇静的时间、机械通气总时间等指标。
结果 三组一般资料、重症疼痛观察(CPOT)评分、治疗前后不同时点MAP和HR、机械通气时间差异无统计学意义,达到理想镇静镇痛的时间C组明显快于A组和B组（P<0.05）。
结论 右美托咪定联合地佐辛较单用右美托咪定及右美托咪定联合芬太尼能更快达到理想镇静镇痛效果。

英文摘要:

      
Objective To evaluate the effects on mechanical ventilation in ICU patients with dexmedetomidine merely and combined with dezocine, fentanyl, respectively.
Methods Fifty-seven patients with mechanical ventilation in ICU were collected during Jun till Dec in 2016, 35 males and 22 females, aged 18-75 years, and classified into three groups with random number table method, among whom there were 17 patients treated with dexmedetomidine, 20 patients treated with dexmedetomidine combined with dezocine and 20 with dexmedetomidine plus fentanyl, the general condition, pain score, MAP and HR were compared before and after the treatment, ideal treatment time and mechanical ventilation time were also compared among the different groups.
Results There were no statistical differences in the general condition, CPOT score, MAP and HR at different points and mechanical ventilation time. Whereas, the time of ideal sedation and analgesia was significantly faster in group C than that of groups A and B (P<0.05).
Conclusion Dexmedetomidine combined with dezocine can reach the ideal analgesic effect more rapidly than dexmedetomidine solely or combined with fentanyl.