全身麻醉引起意识消失的脑网络机制研究进展

Advances in brain network mechanisms of loss of consciousness induced by general anesthesia

摘要:

麻醉与意识的探索一直是神经科学的重要课题，但意识的潜在神经机制尚不清楚，这限制了麻醉监测和意识评估系统的发展。意识的神经相关物（NCC）不能被单一的大脑区域或机制所确定，提示意识可能产生于空间和时间尺度上大脑功能复杂的相互作用。为了表征这种复杂的相互作用，脑网络机制被引入到意识机制的研究中。本文介绍脑网络研究的基本概念和常用指标，综述麻醉相关脑网络研究的最新进展，以期为脑网络指标在临床监测中的应用提供新的思路，同时为NCC的探索提供方向。

Abstract:

The exploration of anesthesia and consciousness has always been an important subject in neuroscience, but the underlying neural mechanisms of consciousness are still unclear, which limits the development of anesthesia monitoring and consciousness evaluation systems. The neural correlates of consciousness (NCC) cannot be determined by a single brain region or mechanism, suggesting that consciousness may arise from complex interactions of brain functions on space and time scales. In order to characterize these interactions, network science has been introduced in exploring the mechanisms of consciousness. In this paper, the basic concepts and common indicators of brain network research are introduced, and the latest progress of brain network research in anesthesia is reviewed, so as to provide new ideas for the application of brain network indicators in clinical monitoring and provide directions for the exploration of NCC.